Long-Range Electron Transport Rates Depend on Wire Dimensions in Cytochrome Nanowires

TitleLong-Range Electron Transport Rates Depend on Wire Dimensions in Cytochrome Nanowires
Publication TypeJournal Article
Year of Publication2023
AuthorsKulke, M, Olson, DM, Huang, J, Kramer, DM, Vermaas, JV
JournalSmall
Volume19
Issue52
Pagination2304013
Date Published2023/12/01
ISBN Number1613-6810
Keywordsgraph theory, Molecular Dynamics Simulations, small tetraheme cytochrome, thermal fluctuations
Abstract

The ability to redirect electron transport to new reactions in living systems opens possibilities to store energy, generate new products, or probe physiological processes. Recent work by Huang et al. showed that 3D crystals of small tetraheme cytochromes (STC) can transport electrons over nanoscopic to mesoscopic distances by an electron hopping mechanism, making them promising materials for nanowires. However, fluctuations at room temperature may distort the nanostructure, hindering efficient electron transport. Classical molecular dynamics simulations of these fluctuations at the nano- and mesoscopic scales allowed us to develop a graph network representation to estimate maximum electron flow that can be driven through STC wires. In longer nanowires, transient structural fluctuations at protein-protein interfaces tended to obstruct efficient electron transfer, but these blockages are ameliorated in thicker crystals where alternative electron transfer pathways become more efficient. The model implies that more flexible proteinprotein interfaces limit the required minimum diameter to carry currents commensurate with conventional electronics.

URLhttps://doi.org/10.1002/smll.202304013
Short TitleSmall